AN UNBIASED VIEW OF LDN-27219 DRUG MECHANISM OF ACTION

One significantly attention-grabbing compound is LDN-27219. When most tTG inhibitors are made to bind towards the protein crosslinking Lively web site, LDN-27219 as an alternative binds to the nucleotide binding pocket of your enzyme although it's in its shut-state conformation, and stabilizes that conformation to forestall crosslinking activity.78